Dear Kristi,

Anterior cingulate (AC) has been a consistent area of activation in the pain neuroimaging studies. Electrophysiological studies in anesthetized rats and conditioned rabbits revealed that a high proportion of AC neurons is activated with noxious stimulation. So there you have it. A tetanus shot is without doubt a noxious stimulation. When you get the shot the anterior cingulate neurons go to work. That really hurts.

Gramps